Complex dynamics emerging in Rule 30 with majority memory

In cellular automata with memory, the unchanged maps of the conventional cellular automata are applied to cells endowed with memory of their past states in some specified interval. We implement Rule 30 automata with a majority memory and show that using the memory function we can transform quasi-chaotic dynamics of classical Rule 30 into domains of travelling structures with predictable behaviour. We analyse morphological complexity of the automata and classify dynamics of gliders (particles, self-localizations) in memory-enriched Rule 30. We provide formal ways of encoding and classifying glider dynamics using de Bruijn diagrams, soliton reactions and quasi-chemical representations

Cuerpos diversos, Tetas Diversas: Acción artística para sensibilizar en igualdad de género y diversidad sexual a través de la cerámica

In this photo essay, we present the development of an artistic action called Diverse Tits. It was carried out during the month of October 2020 with students of the Degree in Primary Education from the Faculty of Teaching at the University of Valencia. This action is part of a research process to analyse and assess the role of artistic actions in awareness-raising processes regarding issues of gender identity and sexual diversity. The experience consists of reflecting on the diversity of our bodies, from an ecofeminist perspective, to vindicate the need of a more humanized, naturalized, egalitarian, respectful of diversity and inclusive institution. This embodied reflection uses the modelling of anthropomorphic clay pots inspired by the artworks of Emma Low as a way to confront the personal experiences of our body. The results consist of multiple awareness actions through the delivery of micro-stories that accompany these objects. Presents to teaching, research administration and services staff of the University.En este fotoensayo, presentamos el desarrollo de la acción Tetas Diversas , realizada durante el mes de octubre de 2020 con alumnado del Grado de Maestro/a en Educación Primaria de la Facultad de Magisterio de la Universitat de València. Esta acción forma parte de un proceso de investigación para analizar y valorar el papel de las acciones artísticas en los procesos de sensibilización respecto a cuestiones de identidad de género y diversidad sexual. La experiencia consiste en la reflexión sobre la diversidad de nuestros cuerpos desde una mirada ecofeminista para reivindicar la necesidad de una institución más humanizada, naturalizada, igualitaria, respetuosa con la diversidad e inclusiva. Esta reflexión encarnada emplea el modelado de macetas de barro antropomorfas inspiradas en los trabajos de la artista Emma Low como forma de enfrentarnos a las experiencias personales de nuestro cuerpo. Los resultados consisten en múltiples acciones de sensibilización a través de la entrega de micro relatos que acompañan a estos objetos a personal docente e investigador o de administración y servicios de la Universidad.Neste ensaio fotográfico, apresentamos o desenvolvimento da ação Mamas Diversas, realizada durante o mês de outubro de 2020 com alunos do Mestrado em Educação Básica da Faculdade de Ensino da Universidade de Valencia. Esta ação faz parte de um processo de pesquisa para analisar e avaliar o papel das ações artísticas nos processos de sensibilização sobre as questões da identidade de gênero e diversidade sexual. A experiência consiste em refletir sobre a diversidade de nossos corpos a partir de uma perspetiva eco feminista para reivindicar a necessidade de uma instituição mais humanizada, naturalizada, igualitária, respeitadora da diversidade e inclusiva. Esta reflexão encarnada usa a modelagem de potes de barro antropomórficos inspirados nas obras da artista Emma Low como forma de confrontar as experiências pessoais do nosso corpo. Os resultados consistem em múltiplas ações de sensibilização através da entrega de micro-histórias que acompanham estes objetos ao corpo docente e investigador ou à administração e serviços da Universidade

Complex dynamics of elementary cellular automata emerging from chaotic rules

We show techniques of analyzing complex dynamics of cellular automata (CA) with chaotic behaviour. CA are well known computational substrates for studying emergent collective behaviour, complexity, randomness and interaction between order and chaotic systems. A number of attempts have been made to classify CA functions on their space-time dynamics and to predict behaviour of any given function. Examples include mechanical computation, \lambda{} and Z-parameters, mean field theory, differential equations and number conserving features. We aim to classify CA based on their behaviour when they act in a historical mode, i.e. as CA with memory. We demonstrate that cell-state transition rules enriched with memory quickly transform a chaotic system converging to a complex global behaviour from almost any initial condition. Thus just in few steps we can select chaotic rules without exhaustive computational experiments or recurring to additional parameters. We provide analysis of well-known chaotic functions in one-dimensional CA, and decompose dynamics of the automata using majority memory exploring glider dynamics and reactions

Designing complex dynamics in cellular automata with memory

Since their inception at Macy conferences in later 1940s, complex systems have remained the most controversial topic of interdisciplinary sciences. The term "complex system" is the most vague and liberally used scientific term. Using elementary cellular automata (ECA), and exploiting the CA classification, we demonstrate elusiveness of "complexity" by shifting space-time dynamics of the automata from simple to complex by enriching cells with memory. This way, we can transform any ECA class to another ECA class - without changing skeleton of cell-state transition function - and vice versa by just selecting a right kind of memory. A systematic analysis displays that memory helps "discover" hidden information and behavior on trivial - uniform, periodic, and nontrivial - chaotic, complex - dynamical systems. © World Scientific Publishing Company

Mutanome and expression of immune response genes in microsatellite stable colon cancer

The aim of this study was to analyze the impact of the mutanome in the prognosis of microsatellite stable stage II CRC tumors. The exome of 42 stage II, microsatellite stable, colon tumors (21 of them relapse) and their paired mucosa were sequenced and analyzed. Although some pathways accumulated more mutations in patients exhibiting good or poor prognosis, no single somatic mutation was associated with prognosis. Exome sequencing data is also valuable to infer tumor neoantigens able to elicit a host immune response. Hence, putative neoantigens were identified by combining information about missense mutations in each tumor and HLAs genotypes of the patients. Under the hypothesis that neoantigens should be correctly presented in order to activate the immune response, expression levels of genes involved in the antigen presentation machinery were also assessed. In addition, CD8A level (as a marker of T-cell infiltration) was measured. We found that tumors with better prognosis showed a tendency to generate a higher number of immunogenic epitopes, and up-regulated genes involved in the antigen processing machinery. Moreover, tumors with higher T-cell infiltration also showed better prognosis. Stratifying by consensus molecular subtype, CMS4 tumors showed the highest association of expression levels of genes involved in the antigen presentation machinery with prognosis. Thus, we hypothesize that a subset of stage II microsatellite stable CRC tumors are able to generate an immune response in the host via MHC class I antigen presentation, directly related with a better prognosis

Genetically determined telomere length and multiple myeloma risk and outcome

This work was partially supported by intramural funds of Univerity of Pisa and DKFZ; by Fondo de Investigaciones Sanitarias (Madrid, Spain) [PI12/02688 to J. S., PI17/02276 to J.S.]; by Instituto de Salud Carlos III, co-funded by FEDER funds —a way to build Europe—[PI14-00613 to V.M.] and by Agency for Management of University and Research Grants (AGAUR) of the Catalan Government (Barcelona, Spain) [2017SGR723 to V.M.]. Open Access funding enabled and organized by Projekt DEAL.Telomeres are involved in processes like cellular growth, chromosomal stability, and proper segregation to daughter cells. Telomere length measured in leukocytes (LTL) has been investigated in different cancer types, including multiple myeloma (MM). However, LTL measurement is prone to heterogeneity due to sample handling and study design (retrospective vs. prospective). LTL is genetically determined; genome-wide association studies identified 11 SNPs that, combined in a score, can be used as a genetic instrument to measure LTL and evaluate its association with MM risk. This approach has been already successfully attempted in various cancer types but never in MM. We tested the "teloscore" in 2407 MM patients and 1741 controls from the International Multiple Myeloma rESEarch (IMMeNSE) consortium. We observed an increased risk for longer genetically determined telomere length (gdTL) (OR = 1.69; 95% CI 1.36-2.11; P = 2.97 x 10(-6) for highest vs. lowest quintile of the score). Furthermore, in a subset of 1376 MM patients we tested the relationship between the teloscore and MM patients survival, observing a better prognosis for longer gdTL compared with shorter gdTL (HR = 0.93; 95% CI 0.86-0.99; P = 0.049). In conclusion, we report convincing evidence that longer gdTL is a risk marker for MM risk, and that it is potentially involved in increasing MM survival.Univerity of PisaHelmholtz AssociationInstituto de Salud Carlos III PI12/02688 PI17/02276Instituto de Salud Carlos IIIEuropean CommissionFEDER funds-a way to build Europe PI14-00613Agency for Management of University and Research Grants (AGAUR) of the Catalan Government (Barcelona, Spain) 2017SGR723Projekt DEA

Grupo español de cirugía torácica asistida por videoimagen: método, auditoría y resultados iniciales de una cohorte nacional prospectiva de pacientes tratados con resecciones anatómicas del pulmón

Introduction: our study sought to know the current implementation of video-assisted thoracoscopic surgery (VATS) for anatomical lung resections in Spain. We present our initial results and describe the auditing systems developed by the Spanish VATS Group (GEVATS). Methods: we conducted a prospective multicentre cohort study that included patients receiving anatomical lung resections between 12/20/2016 and 03/20/2018. The main quality controls consisted of determining the recruitment rate of each centre and the accuracy of the perioperative data collected based on six key variables. The implications of a low recruitment rate were analysed for '90-day mortality' and 'Grade IIIb-V complications'. Results: the series was composed of 3533 cases (1917 VATS; 54.3%) across 33 departments. The centres' median recruitment rate was 99% (25-75th:76-100%), with an overall recruitment rate of 83% and a data accuracy of 98%. We were unable to demonstrate a significant association between the recruitment rate and the risk of morbidity/mortality, but a trend was found in the unadjusted analysis for those centres with recruitment rates lower than 80% (centres with 95-100% rates as reference): grade IIIb-V OR=0.61 (p=0.081), 90-day mortality OR=0.46 (p=0.051). Conclusions: more than half of the anatomical lung resections in Spain are performed via VATS. According to our results, the centre's recruitment rate and its potential implications due to selection bias, should deserve further attention by the main voluntary multicentre studies of our speciality. The high representativeness as well as the reliability of the GEVATS data constitute a fundamental point of departure for this nationwide cohort

Applicability of probabilistic graphical models for early detection of SARS-CoV-2 reactive antibodies after SARS-CoV-2 vaccination in hematological patients

Prior studies of antibody response after full SARS-CoV-2 vaccination in hematological patients have confirmed lower antibody levels compared to the general population. Serological response in hematological patients varies widely according to the disease type and its status, and the treatment given and its timing with respect to vaccination. Through probabilistic machine learning graphical models, we estimated the conditional probabilities of having detectable anti-SARS-CoV-2 antibodies at 3–6 weeks after SARS-CoV-2 vaccination in a large cohort of patients with several hematological diseases (n= 1166). Most patients received mRNA-based vaccines (97%), mainly Moderna® mRNA-1273 (74%) followed by Pfizer-BioNTech® BNT162b2 (23%). The overall antibody detection rate at 3 to 6 weeks after full vaccination for the entire cohort was 79%. Variables such as type of disease, timing of anti-CD20 monoclonal antibody therapy, age, corticosteroids therapy, vaccine type, disease status, or prior infection with SARS-CoV-2 are among the most relevant conditions influencing SARS-CoV-2-IgG-reactive antibody detection. A lower probability of having detectable antibodies was observed in patients with B-cell non-Hodgkin’s lymphoma treated with anti-CD20 monoclonal antibodies within 6 months before vaccination (29.32%), whereas the highest probability was observed in younger patients with chronic myeloproliferative neoplasms (99.53%). The Moderna® mRNA-1273 compound provided higher probabilities of antibody detection in all scenarios. This study depicts conditional probabilities of having detectable antibodies in the whole cohort and in specific scenarios such as B cell NHL, CLL, MM, and cMPN that may impact humoral responses. These results could be useful to focus on additional preventive and/or monitoring interventions in these highly immunosuppressed hematological patients.REDCap is developed and supported by Vanderbilt Institute for Clinical and Translational Research. We thank the Spanish Society of Hematology (SEHH) for its support on the study. We sincerely want to thanks the invaluable aid of microbiology services for their commitment in SARS-CoV-2-reactive IgG antibody monitoring in these highly immunosuppressed patients from all participating centers. Finally, we also want to thank the patients, nurses, and study coordinators for their foremost contributions in this study.Peer reviewe